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B Forest plot displaying the difference in proportions and 95% confidence intervals for the erectile dysfunction adverse events at pre- and post-oral dutasteride treatment. C Forest plot displaying the difference in proportions and 95% confidence intervals for the ejaculation dysfunction adverse events at pre- and post-oral dutasteride treatment. Dutasteride suppresses the production of DHT, a key trigger for the progressive miniaturization of hair follicles that occurs in male AGA. Hair follicles located in the hairline and the vertex/crown area are the first to typically undergo miniaturization in male AGA, which can eventually lead to receding hairline and temples as well as a bald spot in the crown.
Side effects of dutasteride and finasteride
Clinically, dutasteride (0.5 mg per day) and finasteride (1 mg per day) have been used by some doctors to treat AGA and have showed good therapeutic effect. Further clinical studies are needed to explain the effect of different dosage of drugs in treating AGA. There have so far been no UK clinical trials conducted into the safety and effectiveness of dutasteride in the treatment of hair loss.
What should I do if I forget to take a dose?
The typical concentration of the product will depend on whether it’s truly being applied topically (that also means without any microneedling involved) or injected as part of a mesotherapy treatment. You should be aware that the FDA’s approval of oral dutasteride does not mean that this medication can be used in every kind of formulation. In fact, topical dutasteride is not approved in any country for the treatment of any condition. Historically, it’s been assumed that if it’s stronger than finasteride, it may also have the potential to produce more systemic side effects. (1) In order to reduce the risk of such side effects, an alternative formulation, topical dutasteride, is currently being explored.
What Are the Side Effects?
It occurs in a reproducible pattern, causing hair loss in the temples, vertex, and mid frontal scalp. It is hereditary, which means genetics account for approximately 80% of predisposition1. Most patients that do experience sexual side effects find that they go away once the medication is stopped. Dutasteride is currently only approved in the US for enlarged prostate treatment, although it is commonly prescribed by doctors off-label for use in male pattern hair loss. Finasteride is approved by the US Food and Drug Administration (FDA) and other equivalent health boards for the treatment of androgenetic alopecia. However, it has gone through many clinical trials in other countries, including Argentina, Australia, and America.
Bimatoprost is also being investigated as a potential treatment for pattern hair loss. Microneedling is a technique that creates controlled micro-injuries to stimulate skin and hair follicles. Performing this procedure at home can be challenging, and there are typically more benefits to having microneedling done at a clinic.
It’s important to do your research and consult your doctor before starting any combination treatment. Patients may combine dutasteride with natural DHT blockers, such as saw palmetto, to try to improve their outcomes. Natural options may be taken as supplements or used topically while taking oral dutasteride. (30) It’s important to note these natural combinations are not well researched or proven to be safe. DHT is converted from testosterone by enzymes known as 5 alpha-reductase isoenzymes.
Given the current amount of studies that exist and the lack of reported serious side effects, it would be hard to say that topical dutasteride is unsafe. However, topical dutasteride certainly has not been thoroughly researched, especially not in women. There are no established treatment protocols for this medication, and the concentration of the drug still varies substantially across studies.
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You can have a free online questionnaire and image-based consultation with our doctors in minutes to see if treatment with Dutasteride is a good option for your hair loss. Platelet-rich plasma is an autologous preparation of plasma with platelets, growth factors, and cytokines. It was initially used during hair transplantation procedures, with mixed results. Preliminary evidence suggests that platelet-rich plasma may be advantageous in hair regrowth.39 Side effects include redness and pain at injection site and pinpoint bleeding. There’s no standardized dosing regimen or concentration for topical dutasteride products. So unlike minoxidil, which is FDA-approved in concentrations of 2% and 5%, your dutasteride gel, serum, or spray could be sold in a wide range of concentrations.
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As with any medication or treatment, it's important to consult with a healthcare provider before starting to ensure that it's the right option for you and to discuss potential risks and benefits. Finasteride is a popular and effective alternative to dutasteride and can be a good option for those looking for a medication to slow down or prevent hair loss. While Finasteride is generally well-tolerated, it can cause side effects, including decreased libido and erectile dysfunction, although these side effects are usually reversible after stopping the medication.
A pilot study was performed before each phase to assure an adequate inter-rater agreement, defined as a Cohen's kappa coefficient over 0.7. The study selection process was performed in the Distiller-SR software (Evidence Partners). Study data were collected retrospectively from existing patient medical charts, using an electronic CRF (eCRF). Clinical staff abstracted patient information from medical charts into the eCRF.
The medication needs to be used regularly, normally once daily, in order to achieve and maintain hair retention and growth benefits. Dutasteride in its oral form is normally well tolerated by most users, but there is a small chance of side effects. Dutasteride was patented in 1993 and was released in 2001 under the brand name Avodart for the indication of an enlarged prostate, or BPH. After thorough monitoring of a dose and its effects, the conclusion was made in favour of Dutasteride 0.5 mg. Of course the results vary from one person to another, but it has been observed that Dutasteride can regrow hair.
The next best performing medication was a 1mg dosage of oral finasteride, followed by 5% topical minoxidil, 2% topical minoxidil, and lastly 0.25mg per day of oral minoxidil. The effectiveness results reported here are consistent with a systematic review of three clinical trials investigating the efficacy of dutasteride and finasteride in male AGA over 24 weeks. Among 576 participants, dutasteride showed significantly better efficacy than finasteride, as measured by total hair count and investigators’ assessment of the vertex and frontal views18. Despite producing promising results in clinical studies for treating hair loss, dutasteride has not yet been approved by the FDA as a hair loss treatment. Currently, the medications that are available on the market for managing male pattern baldness are limited to finasteride (Propecia) and minoxidil (Rogaine). A board-certified dermatologist, however, such as Dr. Michele Green in NYC, may prescribe oral dutasteride for “off label” use if it is determined to be medically appropriate for a patient.
It's also important to note that not everyone is a good candidate for hair transplant surgery, and results can vary depending on factors like age, hair type, and the extent of hair loss. PRP therapy contains a high concentration of platelets, which are known to contain a variety of growth factors that can help to promote hair growth. Some of these growth factors include platelet-derived growth factor, vascular endothelial growth factor, and transforming growth factor-beta. One of the best things about the Scandinavian Biolabs Hair Growth Routine is that it is drug-free and safe for everyday use. Plus, they offer a 150-day money-back guarantee, so you can try the product risk-free. However, it's important to note that dutasteride should only be taken under the supervision of a healthcare professional, and the dosage may vary depending on the individual's medical history and response to the medication.
Natural DHT blockers are also available, such as the popular nutraceutical saw palmetto. Saw palmetto is an extract that comes from the berries of a type of palm tree. Other nutraceutical DHT blockers include stinging nettle, pumpkin seed oil, lycopene, tea tree oil, and caffeine. However, it binds excessively to some people’s hair follicles, causing them to shrink. Also to consider is the fact that currently there is no standardized intervention protocol for intralesional dutasteride. Future studies should focus on establishing the optimal number of treatments and dosages, frequency, administration techniques, and overall safety.
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